Article
Screening for mutations and polymorphisms in the genes KCNH2 and KCNE2 encoding the cardiac HERG/MiRP1 ion channel: implications for acquired and congenital long Q-T syndrome.
Clinical chemistry - 1 Aug 2001
Larsen L A, Andersen P S, Kanters J, Svendsen I H, Jacobsen J R, Vuust J, Wettrell G, Tranebjaerg L, Bathen J, Christiansen M
Abstract excerpt
BACKGROUND: The voltage-gated, rapid-delayed rectifier current (I(Kr)) is important for repolarization of the heart, and mutations in the genes coding for the K+-ion channel conducting this current, i.e., KCNH2 for the alpha-subunit HERG and KCNE2 for the beta-subunit MiRP1, cause acquired and co...
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