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Article

Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics.

Journal of molecular medicine (Berlin, Germany) - 1 Aug 2002

Isbrandt Dirk, Friederich Patrick, Solth Anna, Haverkamp Wilhelm, Ebneth Andreas, Borggrefe Martin, Funke Harald, Sauter Kathrin, Breithardt Günter, Pongs Olaf, Schulze-Bahr Eric

Abstract excerpt

Long-QT syndrome (LQTS) may cause syncope and sudden death due to cardiac tachyarrhythmia. Chromosome 7-linked LQTS (LQT2) has been correlated with mutations in the human ether-a-go-go-related gene (HERG). HERG forms voltage-gated K channels that may be associated with Mink-related peptide 1 (MiRP1), an auxiliary beta-subunit. The channels mediate currents that resemble native I(Kr). Mutations in the KCNE2 gene...

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Identifiers

PMID: 12185453
DOI: 10.1007/s00109-002-0364-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics.PMID 12185453Read ↗

Screening for mutations and polymorphisms in the genes KCNH2 and KCNE2 encoding the cardiac HERG/MiRP1 ion channel: implications for acquired and congenital long Q-T syndrome.Semantic proximity Read ↗

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KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel.Semantic proximity Read ↗

Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels.Semantic proximity Read ↗

Regulation of the Kv2.1 potassium channel by MinK and MiRP1.Semantic proximity Read ↗

MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac ArrhythmiaSemantic proximity Read ↗

The voltage-gated channel accessory protein KCNE2: multiple ion channel partners, multiple ways to long QT syndrome.Semantic proximity Read ↗

Long QT Syndrome Type 2: Emerging Strategies for Correcting Class 2 KCNH2 (hERG) Mutations and Identifying New PatientsSemantic proximity Read ↗

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Mutations in the hminK gene cause long QT syndrome and suppress IKs function.Semantic proximity Read ↗

Elevated heart rate triggers action potential alternans and sudden death. translational study of a homozygous KCNH2 mutation.Semantic proximity Read ↗

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