Article
Angiotensin II, via AT1 and AT2 receptors and NF-kappaB pathway, regulates the inflammatory response in unilateral ureteral obstruction.
Journal of the American Society of Nephrology : JASN - 1 Jun 2004
Esteban Vanesa, Lorenzo Oscar, Rupérez Mónica, Suzuki Yusuke, Mezzano Sergio, Blanco Julia, Kretzler Mathias, Sugaya Takeshi, Egido Jesús, Ruiz-Ortega Marta
Abstract excerpt
Inflammatory cell infiltration plays a key role in the onset and progression of renal injury. The NF-kappaB participates in the inflammatory response, regulating many proinflammatory genes. Angiotensin II (Ang II), via AT(1) and AT(2) receptors, activates NF-kappaB. Although the contribution of Ang II to kidney damage progression is already established, the receptor subtype involved in the inflammatory cell...
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