Article
The inflammatory cytokine IL-1β is involved in bladder remodeling after bladder outlet obstruction in mice.
Neurourology and urodynamics - 1 Mar 2016
Kanno Yukiko, Mitsui Takahiko, Kitta Takeya, Moriya Kimihiko, Tsukiyama Tadasuke, Hatakeyama Shigetsugu, Nonomura Katsuya
Abstract excerpt
AIMS: We investigated the relationship between IL-1β and morphological and functional changes following partial bladder outlet obstruction (pBOO). METHODS: Female wild-type C57/BL6 mice (WT) and IL-1β-/- mice (KO) were used. Animals were sacrificed either 1 or 3 weeks after pBOO or sham surgery, and their bladders were harvested to determine bladder weight, for RT-PCR to measure interleukin-1β (IL-1β), insulin...
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