Article
The role of the plasminogen activation system in angiogenesis and metastasis.
Surgical oncology clinics of North America - 1 Apr 2001
Rabbani S A, Mazar A P
Abstract excerpt
The urokinase plasminogen activator system (uPA) has been demonstrated to be required for the movement of cells through a matrix. These observations have been extended to the migration of endothelial cells during the process of angiogenesis, and recent data suggest that the uPA system is central to this process. uPA is a serine protease that is capable of initiating an extracellular cascade of proteolysis that...
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