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The Urokinase Plasminogen Activator System in Human Cancers: An Overview of Its Prognostic and Predictive Role

12 Nov 2018

Abstract excerpt

Urokinase plasminogen activator (uPA) system regulates extracellular matrix remodelling by activating ubiquitous protease plasmin in many important physiological processes. The system components include uPA, plasminogen activator inhibitors (PAIs) and uPA receptor (uPAR). Besides its role in physiological processes, uPA system is active in most tumour types where its aberrant regulation has been associated with...

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PMID: 30419600
DOI: 10.1055/s-0038-1675399

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