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Article

Enhanced expression of the leukotriene C(4) synthase due to overactive transcription of an allelic variant associated with aspirin-intolerant asthma.

American journal of respiratory cell and molecular biology - 1 Sept 2000

Sanak M, Pierzchalska M, Bazan-Socha S, Szczeklik A

Abstract excerpt

Aspirin-intolerant asthma (AIA), a distinct clinical syndrome affecting about 10% of adult asthmatics, appears to be unusually dependent on cysteine leukotriene (cys-LT) overproduction by pulmonary eosinophils. The gene coding for leukotriene (LT) C(4) synthase (LTC(4)S), the enzyme controlling cys-LT biosynthesis, exists as two common alleles distinguished by an A to C transversion at a site 444 nucleotides...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 10970818
DOI: 10.1165/ajrcmb.23.3.4051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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