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Article

The A-444C polymorphism in the leukotriene C4 synthase gene is associated with aspirin-induced urticaria.

Journal of investigational allergology & clinical immunology - 1 Jan 2009

Sánchez-Borges M, Acevedo N, Vergara C, Jiménez S, Zabner-Oziel P, Monzón A, Caraballo L

Abstract excerpt

BACKGROUND: Cysteinyl leukotriene production seems to be dysregulated in patients with hypersensitivity to aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs). However, the underlying pathogenic mechanisms of these reactions are poorly understood. Previous studies have suggested a rol...

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PMID: 19862937

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19862937-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The A-444C polymorphism in the leukotriene C4 synthase gene is associated with aspirin-induced urticaria.PMID 19862937Read ↗

The -444A/C polymorphism in the LTC4S gene and the risk of asthma: a meta-analysis.Semantic proximity Read ↗

Characterization of two polymorphisms in the leukotriene C4 synthase gene in an Australian population of subjects with mild, moderate, and severe asthma.Semantic proximity Read ↗

Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant.Semantic proximity Read ↗

Lack of an association between a newly identified promoter polymorphism (-1702G > A) of the leukotriene C4 synthase gene and aspirin-intolerant asthma in a Korean population.Semantic proximity Read ↗

Leukotriene C4 synthase promoter polymorphism in Japanese patients with aspirin-induced asthma.Semantic proximity Read ↗

5' flanking region polymorphism of the gene encoding leukotriene C4 synthase does not correlate with the aspirin-intolerant asthma phenotype in the United States.Semantic proximity Read ↗

What do we know about the genetics of aspirin intolerance?Semantic proximity Read ↗

Hypersensitivity to aspirin: common eicosanoid alterations in urticaria and asthma.Semantic proximity Read ↗

Genetic variability of prostaglandin E2 receptor subtype EP4 gene in aspirin-intolerant chronic urticaria.Semantic proximity Read ↗

Association analysis of cysteinyl-leukotriene receptor 2 (CYSLTR2) polymorphisms with aspirin intolerance in asthmatics.Semantic proximity Read ↗

Differential contribution of the CysLTR1 gene in patients with aspirin hypersensitivity.Semantic proximity Read ↗

Association between leukotriene C4 synthase A-444C polymorphism and asthma in Chinese Han population in Beijing.Semantic proximity Read ↗

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