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Article

Cysteinyl leukotriene receptor 1 promoter polymorphism is associated with aspirin-intolerant asthma in males.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Apr 2006

Kim S-H, Oh J-M, Kim Y-S, Palmer L J, Suh C-H, Nahm D-H, Park H-S

Abstract excerpt

BACKGROUND: Cysteinyl leukotrienes (CysLTs) play important roles in the pathogenesis of eosinophilic airway inflammation characterized by bronchoconstriction, mucus secretion and airway hyper-responsiveness via cysteinyl leukotriene receptor 1 (CysLTR1)-mediated mechanism. CysLTR1-selective antagonists have anti-bronchoconstrictive and anti-inflammatory effects in asthma, particularly aspirin-intolerant asthma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16630147
DOI: 10.1111/j.1365-2222.2006.02457.x

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Cysteinyl leukotriene receptor 1 promoter polymorphism is associated with aspirin-intolerant asthma in males.PMID 16630147Read ↗

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