Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inflated wings, tissue autolysis and early death in tissue inhibitor of metalloproteinases mutants of Drosophila.

European journal of cell biology - 1 Jul 2000

Godenschwege T A, Pohar N, Buchner S, Buchner E

Abstract excerpt

In vertebrates, tissue inhibitors of metalloproteinases (TIMPs) play key roles in extracellular matrix (ECM) homeostasis and growth control. Deletion of the recently cloned Timp gene of Drosophila results in a subviable phenotype. Adult flies display inflated wings similar to integrin mutants, suffer from a bloated gut and progressive dissolution of internal tissues, and die prematurely. Our results demonstrate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abdomen
Share to Blotting, Northern
Share to Cell Adhesion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Matrix

Share to Integrins

Share to Synapsins

Share to Tissue Inhibitor of Metalloproteinases

Share to Wings, Animal

Source

Identifiers

PMID: 10961449
DOI: 10.1078/0171-9335-00072

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inflated wings, tissue autolysis and early death in tissue inhibitor of metalloproteinases mutants of Drosophila.PMID 10961449Read ↗

Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development.Semantic proximity Read ↗

Distinct functions for the catalytic and hemopexin domains of a <i>Drosophila</i> matrix metalloproteinaseSemantic proximity Read ↗

Both Drosophila matrix metalloproteinases have released and membrane-tethered forms but have different substratesSemantic proximity Read ↗

Metalloproteinases in Drosophila to Humans That Are Central Players in Developmental ProcessesSemantic proximity Read ↗

Matrix metalloproteinases and the regulation of tissue remodelling.Semantic proximity Read ↗

MMPs regulate both development and immunity in the tribolium model insect.Semantic proximity Read ↗

Matrix Metalloproteinases are required for membrane motility and lumenogenesis during Drosophila heart development.Semantic proximity Read ↗

Whole Organism Profiling of the Timp Gene FamilySemantic proximity Read ↗

Talin autoinhibition is required for morphogenesis.Semantic proximity Read ↗

Imaginal disc growth factors are <i>Drosophila</i> Chitinase-like Proteins with roles in morphogenesis and CO <sub>2</sub> responseSemantic proximity Read ↗

Genetics of extracellular matrix remodeling during organ growth using the Caenorhabditis elegans pharynx model.Semantic proximity Read ↗

Drosophila MMP2 regulates the matrix molecule faulty attraction (Frac) to promote motor axon targeting in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.