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Article

Matrix Metalloproteinases are required for membrane motility and lumenogenesis during Drosophila heart development.

PloS one - 1 Jan 2017

Raza Qanber S, Vanderploeg Jessica L, Jacobs J Roger

Abstract excerpt

Matrix Metalloproteinases (Mmps) degrade glycoproteins and proteoglycans of the extracellular matrix (ECM) or cell surface and are crucial for morphogenesis. Mmps and their inhibitors are expressed during early stages of cardiac development in vertebrates and expression is altered in multiple congenital cardiomyopathies such as cardia bifida. Drosophila genome encodes two copies of Mmps, Mmp1 and Mmp2 whereas in...

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Identifiers

PMID: 28192468
DOI: 10.1371/journal.pone.0171905
PMCID: PMC5305246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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