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Article

Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development.

Developmental cell - 1 Jan 2003

Page-McCaw Andrea, Serano Julia, Santé Joshua M, Rubin Gerald M

Abstract excerpt

The matrix metalloproteinase (MMP) family is heavily implicated in many diseases, including cancer. The developmental functions of these genes are not clear, however, because the >20 mammalian MMPs can be functionally redundant. Drosophila melanogaster has only two MMPs, which are expressed in embryos in distinct patterns. We created mutations in both genes: Mmp1 mutants have defects in larval tracheal growth and...

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PMID: 12530966
DOI: 10.1016/s1534-5807(02)00400-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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