Article
Genetics of extracellular matrix remodeling during organ growth using the Caenorhabditis elegans pharynx model.
Genetics - 1 Nov 2010
Jafari Gholamali, Burghoorn Jan, Kawano Takehiro, Mathew Manoj, Mörck Catarina, Axäng Claes, Ailion Michael, Thomas James H, Culotti Joseph G, Swoboda Peter, Pilon Marc
Abstract excerpt
The organs of animal embryos are typically covered with an extracellular matrix (ECM) that must be carefully remodeled as these organs enlarge during post-embryonic growth; otherwise, their shape and functions may be compromised. We previously described the twisting of the Caenorhabditis elegans pharynx (here called the Twp phenotype) as a quantitative mutant phenotype that worsens as that organ enlarges during...
Topics
- Alleles
- Animals
- Basement Membrane
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Chromosome Mapping
- Disintegrins
- Extracellular Matrix
- Gene Knockdown Techniques
- Genes, Helminth
- Genotype
- Metalloendopeptidases
- Models, Animal