Article
Drosophila MMP2 regulates the matrix molecule faulty attraction (Frac) to promote motor axon targeting in Drosophila.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Apr 2011
Miller Crystal M, Liu Nan, Page-McCaw Andrea, Broihier Heather T
Abstract excerpt
Matrix metalloproteinases (MMPs) are widely hypothesized to regulate signaling events through processing of extracellular matrix (ECM) molecules. We previously demonstrated that membrane-associated Mmp2 is expressed in exit glia and contributes to motor axon targeting. To identify possible substrates, we undertook a yeast interaction screen for Mmp2-binding proteins and identified the novel ECM protein faulty...
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