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Metalloproteinases in Drosophila to Humans That Are Central Players in Developmental Processes

26 Oct 2011

Abstract excerpt

Many secreted proteins are synthesized as precursors with propeptides that must be cleaved to yield the mature functional form of the molecule. In addition, various growth factors occur in extracellular latent complexes with protein antagonists and are activated upon cleavage of such antagonists. Research in the separate fields of embryonic patterning and extracellular matrix formation has identified members of...

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PMID: 22027825
DOI: 10.1074/jbc.r111.299768

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