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Article

Regulated cleavage of a contact-mediated axon repellent.

Science (New York, N.Y.) - 25 Aug 2000

Hattori M, Osterfield M, Flanagan J G

Abstract excerpt

Contact-mediated axon repulsion by ephrins raises an unresolved question: these cell surface ligands form a high-affinity multivalent complex with their receptors present on axons, yet rather than being bound, axons can be rapidly repelled. We show here that ephrin-A2 forms a stable complex with the metalloprotease Kuzbanian, involving interactions outside the cleavage region and the protease domain. Eph receptor...

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Identifiers

PMID: 10958785
DOI: 10.1126/science.289.5483.1360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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