Regulated cleavage of a contact-mediated axon repellent.

doi:10.1126/science.289.5483.1360

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Article

Regulated cleavage of a contact-mediated axon repellent.

Science (New York, N.Y.) - 25 Aug 2000

Hattori M, Osterfield M, Flanagan J G

Abstract excerpt

Contact-mediated axon repulsion by ephrins raises an unresolved question: these cell surface ligands form a high-affinity multivalent complex with their receptors present on axons, yet rather than being bound, axons can be rapidly repelled. We show here that ephrin-A2 forms a stable complex with the metalloprotease Kuzbanian, involving interactions outside the cleavage region and the protease domain. Eph receptor...

Topics

Amino Acid Motifs
Amino Acid Sequence
Animals
Axons
Cell Adhesion
Cell Communication
Cell Membrane
Cells, Cultured
Disintegrins
Drosophila Proteins
Ephrin-A2
Gene Expression
Glycosylphosphatidylinositols
Growth Cones
Humans
Ligands
Metalloendopeptidases
Mice

Source

Open in PubMed

Identifiers

PMID: 10958785
DOI: 10.1126/science.289.5483.1360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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