Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proteolytic cleavage of Slit by the Tolkin protease converts an axon repulsion cue to an axon growth cue in vivo.

Development (Cambridge, England) - 29 Oct 2020

Kellermeyer Riley, Heydman Leah M, Gillis Taylor, Mastick Grant S, Song Minmin, Kidd Thomas

Abstract excerpt

Slit is a secreted protein that has a canonical function of repelling growing axons from the CNS midline. The full-length Slit (Slit-FL) is cleaved into Slit-N and Slit-C fragments, which have potentially distinct functions via different receptors. Here, we report that the BMP-1/Tolloid family metalloprotease Tolkin (Tok) is responsible for Slit proteolysis in vivo and in vitro. In Drosophilatok mutants lacking...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axons
Share to Cell Membrane

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drosophila melanogaster

Share to Drosophila Proteins

Share to Epistasis, Genetic

Share to Extracellular Space

Share to Nerve Tissue Proteins

Share to Proteolysis

Source

Open in PubMed Open full text

Identifiers

PMID: 32994163
DOI: 10.1242/dev.196055
PMCID: PMC7648596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proteolytic cleavage of Slit by the Tolkin protease converts an axon repulsion cue to an axon growth cue in vivo.PMID 32994163Read ↗

slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains.Semantic proximity Read ↗

Dscam1 Forms a Complex with Robo1 and the N-Terminal Fragment of Slit to Promote the Growth of Longitudinal Axons.Semantic proximity Read ↗

PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments.Semantic proximity Read ↗

Slit/Robo-mediated axon guidance in Tribolium and Drosophila: divergent genetic programs build insect nervous systems.Semantic proximity Read ↗

Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.Semantic proximity Read ↗

Repellent signaling by Slit requires the leucine-rich repeats.Semantic proximity Read ↗

Axon guidance: starting and stopping with slit.Semantic proximity Read ↗

Slit is the midline repellent for the robo receptor in Drosophila.Semantic proximity Read ↗

Short-range and long-range guidance by Slit and its Robo receptors: a combinatorial code of Robo receptors controls lateral position.Semantic proximity Read ↗

In Vivo Functional Analysis of Drosophila Robo1 Fibronectin Type-III Repeats.Semantic proximity Read ↗

The Drosophila immunoglobulin gene turtle encodes guidance molecules involved in axon pathfinding.Semantic proximity Read ↗

Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.