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Article

Proteolysis of EphA2 Converts It from a Tumor Suppressor to an Oncoprotein.

Cancer research - 15 Aug 2015

Koshikawa Naohiko, Hoshino Daisuke, Taniguchi Hiroaki, Minegishi Tomoko, Tomari Taizo, Nam Sung-Ouk, Aoki Mikiko, Sueta Takayuki, Nakagawa Takashi, Miyamoto Shingo, Nabeshima Kazuki, Weaver Alissa M, Seiki Motoharu

Abstract excerpt

Eph receptor tyrosine kinases are considered candidate therapeutic targets in cancer, but they can exert opposing effects on cell growth. In the presence of its ligands, Eph receptor EphA2 suppresses signaling by other growth factor receptors, including ErbB, whereas ligand-independent activation of EphA2 augments ErbB signaling. To deploy EphA2-targeting drugs effectively in tumors, the anti-oncogenic...

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Share to Matrix Metalloproteinase 14
Share to Microscopy, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Metastasis

Share to Oncogene Proteins

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Source

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Identifiers

PMID: 26130649
DOI: 10.1158/0008-5472.CAN-14-2798
PMCID: PMC4682662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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