Article
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
Developmental cell - 7 Dec 2015
van Erp Susan, van den Heuvel Dianne M A, Fujita Yuki, Robinson Ross A, Hellemons Anita J C G M, Adolfs Youri, Van Battum Eljo Y, Blokhuis Anna M, Kuijpers Marijn, Demmers Jeroen A A, Hedman Håkan, Hoogenraad Casper C, Siebold Christian, Yamashita Toshihide, Pasterkamp R Jeroen
Abstract excerpt
Many guidance receptors are proteolytically cleaved by membrane-associated metalloproteases of the ADAM family, leading to the shedding of their ectodomains. Ectodomain shedding is crucial for receptor signaling and function, but how this process is controlled in neurons remains poorly understood. Here, we show that the transmembrane protein Lrig2 negatively regulates ADAM-mediated guidance receptor proteolysis...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.