Article
EphA4 receptor shedding regulates spinal motor axon guidance.
Current biology : CB - 20 Oct 2014
Gatto Graziana, Morales Daniel, Kania Artur, Klein Rüdiger
Abstract excerpt
BACKGROUND: Proteolytic processing of axon guidance receptors modulates their expression and functions. Contact repulsion by membrane-associated ephrins and Eph receptors was proposed to be facilitated by ectodomain cleavage, but whether this phenomenon is required for axon guidance in vivo is unknown. RESULTS: In support of established models, we find that cleavage of EphA4 promotes cell-cell and growth...
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