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Article

Clinical value of alterations in p73 gene, related to p53 at 1p36, in human hepatocellular carcinoma.

International journal of oncology - 1 Feb 2004

Aoki Taro, Miyamoto Atsushi, Marubashi Shigeru, Nagano Hiroaki, Umeshita Koji, Fujiwara Yoshiyuki, Dono Keizo, Nakamori Shoji, Sakon Masato, Monden Morito

Abstract excerpt

A novel gene, p73, encoding a protein with significant homology to p53 and showing functional similarities to p53, was identified at chromosome 1p36, at which tumor suppressor gene of hepatocellular carcinoma (HCC) is supposed to be. Involvement of p73 in hepatocarcinogenesis is controversial and clinical value of p73 alterations remains obscure. We investigated allelic status of p73 in 63 patients with HCC. Loss...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14719122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Clinical value of alterations in p73 gene, related to p53 at 1p36, in human hepatocellular carcinoma.PMID 14719122Read ↗

Absence of mutation of the p73 gene localized at chromosome 1p36.3 in hepatocellular carcinoma.Semantic proximity Read ↗

Genetic alternations of p73 are infrequent but may occur in early stage hepatocellular carcinoma.Semantic proximity Read ↗

Mutational analysis of the p73 gene localized at chromosome 1p36.3 in colorectal carcinomas.Semantic proximity Read ↗

p73, a gene related to p53, is not mutated in esophageal carcinomas.Semantic proximity Read ↗

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers.Semantic proximity Read ↗

Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers.Semantic proximity Read ↗

The p73 gene is not mutated in oligodendrogliomas which frequently have a deleted region at chromosome 1p36.3.Semantic proximity Read ↗

Frequent allelic losses on the short arm of chromosome 1 and decreased expression of the p73 gene at 1p36.3 in squamous cell carcinoma of the oral cavity.Semantic proximity Read ↗

p73 gene alterations and expression in primary oral and laryngeal squamous carcinomas.Semantic proximity Read ↗

Mutation analysis of the p73 gene in nonastrocytic brain tumours.Semantic proximity Read ↗

Polymorphism of the p73 gene in relation to colorectal cancer risk and survival.Semantic proximity Read ↗

Frequent inactivation of the <i>p73</i> gene by abnormal methylation or LOH in non‐Hodgkin's lymphomasSemantic proximity Read ↗

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