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Article

p73, a gene related to p53, is not mutated in esophageal carcinomas.

International journal of cancer - 9 Nov 1998

Nimura Y, Mihara M, Ichimiya S, Sakiyama S, Seki N, Ohira M, Nomura N, Fujimori M, Adachi W, Amano J, He M, Ping Y M, Nakagawara A

Abstract excerpt

A novel gene, termed p73, encodes a protein with a significant homology to p53 and has been mapped at chromosome 1p36.3, which is a locus of multiple suppressor genes for tumors including neuroblastoma and other cancers. Since the 1p36 locus is reported to be deleted and p53 is frequently mutated in esophageal carcinomas, we examined loss of heterozygosity (LOH) and mutation of the p73 gene in 48 untreated...

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Identifiers

PMID: 9797131
DOI: 10.1002/(sici)1097-0215(19981109)78:4<437::aid-ijc8>3.0.co;2-v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

p73, a gene related to p53, is not mutated in esophageal carcinomas.PMID 9797131Read ↗

p73 gene alterations and expression in primary oral and laryngeal squamous carcinomas.Semantic proximity Read ↗

Mutational analysis of the p73 gene localized at chromosome 1p36.3 in colorectal carcinomas.Semantic proximity Read ↗

Absence of mutation of the p73 gene localized at chromosome 1p36.3 in hepatocellular carcinoma.Semantic proximity Read ↗

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers.Semantic proximity Read ↗

Mutational analysis of the p73 gene in human breast cancers.Semantic proximity Read ↗

Infrequent somatic mutations of the p73 gene in various human cancers.Semantic proximity Read ↗

The p73 polymorphisms are not associated with susceptibility to esophageal squamous cell carcinoma in a high incidence region of China.Semantic proximity Read ↗

A common p73 polymorphism is associated with a reduced incidence of oesophageal carcinoma.Semantic proximity Read ↗

Clinical value of alterations in p73 gene, related to p53 at 1p36, in human hepatocellular carcinoma.Semantic proximity Read ↗

p73 mutations are not detected in sporadic and hereditary breast cancer.Semantic proximity Read ↗

Frequent allelic losses on the short arm of chromosome 1 and decreased expression of the p73 gene at 1p36.3 in squamous cell carcinoma of the oral cavity.Semantic proximity Read ↗

Molecular alterations of p73 in human esophageal squamous cell carcinomas: loss of heterozygosity occurs frequently; loss of imprinting and elevation of p73 expression may be related to defective p53.Semantic proximity Read ↗

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