Article
p73, a gene related to p53, is not mutated in esophageal carcinomas.
International journal of cancer - 9 Nov 1998
Nimura Y, Mihara M, Ichimiya S, Sakiyama S, Seki N, Ohira M, Nomura N, Fujimori M, Adachi W, Amano J, He M, Ping Y M, Nakagawara A
Abstract excerpt
A novel gene, termed p73, encodes a protein with a significant homology to p53 and has been mapped at chromosome 1p36.3, which is a locus of multiple suppressor genes for tumors including neuroblastoma and other cancers. Since the 1p36 locus is reported to be deleted and p53 is frequently mutated...
Topics
- Adenocarcinoma
- Alternative Splicing
- Carcinoma, Squamous Cell
- Chromosome Mapping
- Chromosomes, Human, Pair 1
- DNA-Binding Proteins
- Esophageal Neoplasms
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Humans
- Introns
- Loss of Heterozygosity
- Mutation
- Nuclear Proteins