Article
Identification of two distinct deleted regions on the short arm of chromosome 1 and rare mutation of the CDKN2C gene from 1p32 in oligodendroglial tumors.
Journal of neuropathology and experimental neurology - 1 Oct 1999
Husemann K, Wolter M, Büschges R, Boström J, Sabel M, Reifenberger G
Abstract excerpt
Oligodendroglial tumors frequently show allelic losses on the short arm of chromosome 1. To narrow down the putative tumor suppressor gene site(s) on 1p, we have investigated 35 oligodendrogliomas and 10 mixed gliomas (oligoastrocytomas) for loss of heterozygosity (LOH) at 21 highly polymorphic loci on chromosome 1 (19 loci on 1p and 2 loci on 1q). LOH at loci on 1p was found in 30 of the 45 tumors (67%). Two...
Topics
- Adult
- Aged
- Alleles
- Brain Neoplasms
- Carrier Proteins
- Cell Cycle Proteins
- Chromosome Mapping
- Chromosomes, Human, Pair 1
- Cyclin-Dependent Kinase Inhibitor p18
- Enzyme Inhibitors
- Female
- Gene Deletion
- Glioma