Article
Mutational analysis of the p73 gene localized at chromosome 1p36.3 in colorectal carcinomas.
International journal of oncology - 1 Aug 1998
Sunahara M, Ichimiya S, Nimura Y, Takada N, Sakiyama S, Sato Y, Todo S, Adachi W, Amano J, Nakagawara A
Abstract excerpt
Genetic alteration of p53, which monitors DNA damage and operates cellular checkpoints, is a major factor in the development of human colorectal carcinoma (CRC). Recently, p73, a novel family member of p53, has been identified and found, like p53, to activate p21Waf1/Cip1 and to induce apoptosis....
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Chromosomes, Human, Pair 1
- Colorectal Neoplasms
- DNA Mutational Analysis
- DNA, Neoplasm
- Genes, Tumor Suppressor
- Genes, p53
- Humans
- Loss of Heterozygosity
- Middle Aged
- Neoplasm Proteins
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Transcription, Genetic