Article
Motor neuron cell death in wobbler mutant mice follows overexpression of the G-protein-coupled, protease-activated receptor for thrombin.
Molecular medicine (Cambridge, Mass.) - 1 May 2000
Festoff B W, D'Andrea M R, Citron B A, Salcedo R M, Smirnova I V, Andrade-Gordon P
Abstract excerpt
BACKGROUND: Mechanisms underlying neurodegeneration are actively sought for new therapeutic strategies. Transgenic, knockout and genetic mouse models greatly aid our understanding of the mechanisms for neuronal cell death. A naturally occurring, autosomal recessive mutant, known as wobbler, and mice transgenic for familial amyotrophic lateral sclerosis (FALS) superoxide dismutase (SOD)1 mutations are available,...
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