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Article

Brain Protease Activated Receptor 1 Pathway: A Therapeutic Target in the Superoxide Dismutase 1 (SOD1) Mouse Model of Amyotrophic Lateral Sclerosis.

International journal of molecular sciences - 12 May 2020

Shavit-Stein Efrat, Abu Rahal Ihab, Bushi Doron, Gera Orna, Sharon Roni, Gofrit Shany G, Pollak Lea, Mindel Kate, Maggio Nicola, Kloog Yoel, Chapman Joab, Dori Amir

Abstract excerpt

Glia cells are involved in upper motor neuron degeneration in amyotrophic lateral sclerosis (ALS). Protease activated receptor 1 (PAR1) pathway is related to brain pathologies. Brain PAR1 is located on peri-synaptic astrocytes, adjacent to pyramidal motor neurons, suggesting possible involvement in ALS. Brain thrombin activity in superoxide dismutase 1 (SOD1) mice was measured using a fluorometric assay, and PAR1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32408605
DOI: 10.3390/ijms21103419
PMCID: PMC7279358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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