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Article

Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are vulnerable to injury.

Journal of neurochemistry - 1 Jul 2006

Ishii Yoko, Oya Takeshi, Zheng Lianshun, Gao Zhiyang, Kawaguchi Makoto, Sabit Hemragul, Matsushima Takako, Tokunaga Ayano, Ishizawa Shin, Hori Etsuro, Nabeshima Yo-ichi, Sasaoka Toshikuni, Fujimori Toshihiko, Mori Hisashi, Sasahara Masakiyo

Abstract excerpt

Platelet-derived growth factors (PDGFs) and PDGF receptors (PDGFRs) are widely expressed in the mammalian CNS, though their functional significance remains unclear. The corresponding null-knockout mutations are lethal. Here, we developed novel mutant mice in which the gene encoding the beta subunit of PDGFR (PDGFR-beta) was genetically deleted in CNS neurons to elucidate the role of PDGFR-beta, particularly in...

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Identifiers

PMID: 16805849
DOI: 10.1111/j.1471-4159.2006.03922.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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