Article
Differential expression of apoptotic markers in jimpy and in Plp overexpressors: evidence for different apoptotic pathways.
Journal of neurocytology - 1 Jan 2000
Cerghet M, Bessert D A, Nave K A, Skoff R P
Abstract excerpt
Point mutations and duplications of proteolipid protein (PLP) gene in mammals cause dysmyelination and oligodendrocyte cell death. The jimpy mouse, which has a lethal Plp point mutation, is the best characterized of the mutants; transgenic mice, which have additional copies of Plp gene, are less characterized. While oligodendrocyte death is a prominent feature in jimpy, the pathways leading to death have not been...
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