Article
Purkinje neuron degeneration in nervous (nr) mutant mice is mediated by a metabolic pathway involving excess tissue plasminogen activator.
Proceedings of the National Academy of Sciences of the United States of America - 16 May 2006
Li Jianxue, Ma Yinghua, Teng Yang D, Zheng Kangni, Vartanian Timothy K, Snyder Evan Y, Sidman Richard L
Abstract excerpt
Purkinje neurons (PNs), the central cells in cerebellar circuitry and function, constitute a vulnerable population in many human genetic, malignant, hypoxic, and toxic diseases. In the nervous (nr) mutant mouse, the majority of PNs die in the fourth to fifth postnatal weeks, but the responsible molecules are unknown. We first disclose a remarkable increase in mRNA expression and protein concentration in the nr...
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