Article
Genetic polymorphisms in human liver phenol sulfotransferases involved in the bioactivation of N-hydroxy derivatives of carcinogenic arylamines and heterocyclic amines.
Chemico-biological interactions - 20 Feb 1998
Ozawa S, Tang Y M, Yamazoe Y, Kato R, Lang N P, Kadlubar F F
Abstract excerpt
Three related forms of phenol sulfotransferase (PSULT), thermostable ST1A2 (SULT1A2hum) and ST1A3 (SULT1A1hum) and a thermolabile TL-PST (SULT1A3hum), are known to exist in human livers. Thermostable forms, whose activities are polymorphically distributed, have been shown to mediate the bioactiva...
Topics
- Amines
- Arylsulfotransferase
- Biotransformation
- Carcinogens
- Genotype
- Heterocyclic Compounds
- Humans
- Isoenzymes
- Liver
- Polymerase Chain Reaction
- Polymorphism, Genetic
- RNA, Messenger
- Transcription, Genetic