Article
Multipoint linkage analysis of a candidate gene locus in rheumatoid arthritis demonstrates significant evidence of linkage and association with the corticotropin-releasing hormone genomic region.
Arthritis and rheumatism - 1 Aug 2000
Fife M S, Fisher S A, John S, Worthington J, Shah C J, Ollier W E, Panayi G S, Lewis C M, Lanchbury J S
Abstract excerpt
OBJECTIVE: Rheumatoid arthritis (RA) is the most common disabling autoimmune disease, affecting approximately 1% of the population. The disease etiology is unknown, but it involves inflammation and immune dysregulation and is influenced by genetic variation at both HLA and other, as-yet-unidentified genetic loci. Corticotropin-releasing hormone (CRH; or corticotropin-releasing factor), a primary regulator of the...
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