Article
Association of familial and sporadic rheumatoid arthritis with a single corticotropin-releasing hormone genomic region (8q12.3) haplotype.
Arthritis and rheumatism - 1 Jan 2002
Fife Mark, Steer Sophia, Fisher Sheila, Newton Julia, McKay Kirsten, Worthington Jane, Shah Chandrabala, Polley Andreas, Rosenthal Andre, Ollier William, Lewis Cathryn, Wordsworth Paul, Lanchbury Jerry
Abstract excerpt
OBJECTIVE: Rheumatoid arthritis (RA) is a common disabling autoimmune disease with a complex genetic component. We have previously described linkage of a region of chromosome 8q12.3 with RA and association of the microsatellite marker CRHRA1 with RA in 295 affected sibling-pair families. In the current study we aimed to physically link the RA-associated marker with the corticotropin-releasing hormone (CRH)...
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