Article
Association study between corticotrophin-releasing hormone genomic region (8q13) and rheumatoid arthritis in the Spanish population.
Rheumatology (Oxford, England) - 1 Dec 2003
Julià A, Gallardo D, Vidal F, De Agustín J J, Barceló P, Vilardell M, Marsal S
Abstract excerpt
OBJECTIVE: To investigate whether the corticotrophin-releasing hormone (CRH) genomic region confers genetic susceptibility to rheumatoid arthritis (RA) in the Spanish population. METHODS: DNA was obtained from 121 simplex RA families and 101 healthy controls, all from Spanish origin. Two microsatellites, CRHRA1 and CRHRA2, located 25 and 20 kb downstream respectively from the CRH gene were examined using a new...
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