Article
A genome-wide scan for juvenile rheumatoid arthritis in affected sibpair families provides evidence of linkage.
Arthritis and rheumatism - 1 Sept 2004
Thompson Susan D, Moroldo Marta B, Guyer Laura, Ryan Mary, Tombragel Esther M, Shear Edith S, Prahalad Sampath, Sudman Marc, Keddache Mehdi A, Brown W Mark, Giannini Edward H, Langefeld Carl D, Rich Stephen S, Nichols William C, Glass David N
Abstract excerpt
OBJECTIVE: Juvenile rheumatoid arthritis (JRA) represents a heterogeneous group of disorders with a complex genetic component. A genome scan was performed to detect linkage to JRA in 121 families containing 247 affected children in North America (the JRA Affected Sibpair [ASP] Registry). METHODS: Genotype data collected for HLA-DR and 386 microsatellite markers were subjected to multipoint nonparametric linkage...
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