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Article

The potassium chloride cotransporter KCC-2 coordinates development of inhibitory neurotransmission and synapse structure in Caenorhabditis elegans.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 12 Aug 2009

Tanis Jessica E, Bellemer Andrew, Moresco James J, Forbush Biff, Koelle Michael R

Abstract excerpt

Chloride influx through GABA-gated chloride channels, the primary mechanism by which neural activity is inhibited in the adult mammalian brain, depends on chloride gradients established by the potassium chloride cotransporter KCC2. We used a genetic screen to identify genes important for inhibition of the hermaphrodite-specific motor neurons (HSNs) that stimulate Caenorhabditis elegans egg-laying behavior and...

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Identifiers

PMID: 19675228
DOI: 10.1523/JNEUROSCI.1989-09.2009
PMCID: PMC2737711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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