Article
Genetics of atopy in a mouse model: polymorphism of the IL-5 receptor alpha chain.
Immunogenetics - 1 Jul 2000
Daser A, Koetz K, Bätjer N, Jung M, Rüschendorf F, Goltz M, Ellerbrok H, Renz H, Walter J, Paulsen M
Abstract excerpt
To study the genetics of atopy systematically we established a mouse model that provides the general phenotype of atopy: the early response characteristic of IgE-dependent eczema or atopic dermatitis, and the diagnostic test of atopy, the skin-prick test. Using an immediate cutaneous hypersensitivity test (ICHS) against birch pollen extract we could classify A/J and C57BL/6 (B6) inbred mouse strains respectively...
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