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Article

Multistrain genetic comparisons reveal CCR5 as a receptor involved in airway hyperresponsiveness.

American journal of respiratory cell and molecular biology - 1 Jun 2006

Walker Julia K L, Ahumada Adriana, Frank Bryan, Gaspard Renee, Berman Katherine, Quackenbush John, Schwartz David A

Abstract excerpt

Asthma is a ubiquitous disease with a broad range of clinical phenotypes. To better understand the complex genetic and environmental interactions underlying asthma, we compared the gene-gene interactions of four genetically distinct mouse strains that demonstrate biologically distinct responses to allergen. Using DNA microarrays and knock-out mouse studies, we showed that CCR5 plays a definitive role in the...

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Source

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Identifiers

PMID: 16474097
DOI: 10.1165/rcmb.2005-0314OC
PMCID: PMC2644233

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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