Article
FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen.
Proceedings of the National Academy of Sciences of the United States of America - 5 Dec 1995
Smith K G, Nossal G J, Tarlinton D M
Abstract excerpt
In establishing the memory B-cell population and maintaining self-tolerance during an immune response, apoptosis mediates the removal of early, low-affinity antibody-forming cells, unselected germinal center (GC) cells, and, potentially, self-reactive B cells. To address the role of the apoptosis...
Topics
- Amino Acid Sequence
- Animals
- Antibody Affinity
- Antibody Formation
- Antibody-Producing Cells
- B-Lymphocytes
- Base Sequence
- Germinal Center
- Haptens
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Immunologic Memory
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutation
- Nitrophenols