Article
FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen.
Proceedings of the National Academy of Sciences of the United States of America - 5 Dec 1995
Smith K G, Nossal G J, Tarlinton D M
Abstract excerpt
In establishing the memory B-cell population and maintaining self-tolerance during an immune response, apoptosis mediates the removal of early, low-affinity antibody-forming cells, unselected germinal center (GC) cells, and, potentially, self-reactive B cells. To address the role of the apoptosis-signaling cell surface molecule FAS in the B-cell response to antigen, we have examined the T-cell-dependent B-cell...
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