Article
Amplified follicular immune complex deposition in mice lacking the Fc receptor gamma-chain does not alter maturation of the B cell response.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 1997
Vora K A, Ravetch J V, Manser T
Abstract excerpt
The role of Ag-Ab complexes (or immune complexes; ICs) in the regulation of the maturation of the B cell immune response was investigated in mice perturbed in the deposition and retention of such complexes. Loss of surface expression of Fc gammaRI and Fc gammaRIII due to targeted disruption of th...
Topics
- Animals
- Antigen-Antibody Complex
- B-Lymphocytes
- Base Sequence
- Cell Differentiation
- Clonal Deletion
- Dendritic Cells
- Female
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Genes, Immunoglobulin
- Genotype
- Germinal Center
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Immunologic Memory
- Male
- Mice
- Mice, Inbred C57BL