Article
Presynaptic glutamic acid decarboxylase is required for induction of the postsynaptic receptor field at a glutamatergic synapse.
Neuron - 1 Jul 2000
Featherstone D E, Rushton E M, Hilderbrand-Chae M, Phillips A M, Jackson F R, Broadie K
Abstract excerpt
We have systematically screened EMS-mutagenized Drosophila for embryonic lethal strains with defects in glutamatergic synaptic transmission. Surprisingly, this screen led to the identification of several alleles with missense mutations in highly conserved regions of Dgad1. Analysis of these gad mutants reveals that they are paralyzed owing to defects in glutamatergic transmission at the neuromuscular junction....
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