Functional reconstitution of Drosophila melanogaster NMJ glutamate receptors.

doi:10.1073/pnas.1500458112

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Article

Functional reconstitution of Drosophila melanogaster NMJ glutamate receptors.

Proceedings of the National Academy of Sciences of the United States of America - 12 May 2015

Han Tae Hee, Dharkar Poorva, Mayer Mark L, Serpe Mihaela

Abstract excerpt

The Drosophila larval neuromuscular junction (NMJ), at which glutamate acts as the excitatory neurotransmitter, is a widely used model for genetic analysis of synapse function and development. Despite decades of study, the inability to reconstitute NMJ glutamate receptor function using heterologous expression systems has complicated the analysis of receptor function, such that it is difficult to resolve the...

Topics

Amino Acid Sequence
Animals
Calcium
Cell Membrane
Crystallography, X-Ray
DNA, Complementary
Drosophila Proteins
Drosophila melanogaster
Ions
Ligands
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microscopy, Confocal

Molecular Sequence Data

Mutation

Neuromuscular Junction

Oocytes

Permeability

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 25918369
DOI: 10.1073/pnas.1500458112
PMCID: PMC4434721

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