Article
Cytosolic tail sequences and subunit interactions are critical for synaptic localization of glutamate receptors.
Journal of cell science - 1 May 2005
Chang Howard Chia-Hao, Rongo Christopher
Abstract excerpt
AMPA-type glutamate receptors mediate excitatory synaptic transmission in the nervous system. The receptor subunit composition and subcellular localization play an important role in regulating synaptic strength. GLR-1 and GLR-2 are the Caenorhabditis elegans subunits most closely related to the mammalian AMPA-type receptors. These subunits are expressed in overlapping sets of interneurons, and contain type-I PDZ...
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