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Article

Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions.

Nature genetics - 1 Aug 2000

Brown C W, Houston-Hawkins D E, Woodruff T K, Matzuk M M

Abstract excerpt

The activins (dimers of betaA or betaB subunits, encoded by the genes Inhba and Inhbb, respectively) are TGF-beta superfamily members that have roles in reproduction and development. Whereas mice homozygous for the Inhba-null allele demonstrate disruption of whisker, palate and tooth development, leading to neonatal lethality, homozygous Inhbb-null mice are viable, fertile and have eye defects. To determine if...

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Identifiers

PMID: 10932194
DOI: 10.1038/78161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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