Targeted disruption of the <i>Hoxb-2</i> locus in mice interferes with expression of <i>Hoxb-1</i> and <i>Hoxb-4</i>

Abstract excerpt

Mice with a disruption in the hoxb-2 locus were generated by gene targeting. 75% of the hoxb-2 mutant homozygotes died within 24 hours of birth. While a majority of these mice had severe sternal defects that compromised their ability to breathe, some had relatively normal sternum morphology, suggesting that one or more additional factor(s) contributed to neonatal lethality. At 3-3.5 weeks of age, half of the...

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