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Article

Activins Are Critical Modulators of Growth and Survival

14 Oct 2003

Abstract excerpt

Activins betaA and betaB (encoded by Inhba and Inhbb genes, respectively) are related members of the TGF-beta superfamily. Previously, we generated mice with an Inhba knock-in allele (InhbaBK) that directs the expression of activin betaB protein in the spatiotemporal pattern of activin betaA. These mice were small and had shortened life spans, both influenced by the dose of the hypomorphic InhbaBK allele. To...

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Identifiers

PMID: 14551263
DOI: 10.1210/me.2003-0051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activins Are Critical Modulators of Growth and SurvivalPMID 14551263Read ↗

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Activin A Balances Sertoli and Germ Cell Proliferation in the Fetal Mouse TestisSemantic proximity Read ↗

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Normal reproductive function in InhBP/p120-deficient mice.Semantic proximity Read ↗

Inhibin-A Antagonizes TGFβ2 Signaling by Down-Regulating Cell Surface Expression of the TGFβ Coreceptor BetaglycanSemantic proximity Read ↗

Genetic analysis of activin/inhibin β subunits in zebrafish development and reproductionSemantic proximity Read ↗

GDF9 modulates the reproductive and tumor phenotype of female inha-null mice.Semantic proximity Read ↗

Human INHBB Gene Variant (c.1079T>C:p.Met360Thr) Alters Testis Germ Cell Content, but Does Not Impact Fertility in Mice.Semantic proximity Read ↗

Activins, Myostatin and Related TGF-β Family Members as Novel Therapeutic Targets for Endocrine, Metabolic and Immune DisordersSemantic proximity Read ↗

Human and mouse activin genes: Divergent expression of activin A protein variants and identification of a novel heparan sulfate-binding domain in activin B.Semantic proximity Read ↗

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