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Article

Normal reproductive function in InhBP/p120-deficient mice.

Molecular and cellular biology - 1 Jul 2003

Bernard Daniel J, Burns Kathleen H, Haupt Bisong, Matzuk Martin M, Woodruff Teresa K

Abstract excerpt

The inhibins are gonadal transforming growth factor beta superfamily protein hormones that suppress pituitary follicle-stimulating hormone (FSH) synthesis. Recently, betaglycan and inhibin binding protein (InhBP/p120, also known as the product of immunoglobulin superfamily gene 1 [IGSF1]) were identified as candidate inhibin coreceptors, shedding light on the molecular basis of how inhibins may affect target...

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Source

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Identifiers

PMID: 12832474
DOI: 10.1128/MCB.23.14.4882-4891.2003
PMCID: PMC162213

Genes

IGSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Normal reproductive function in InhBP/p120-deficient mice.PMID 12832474Read ↗

Luteinizing hormone promotes gonadal tumorigenesis in inhibin-deficient mice.Semantic proximity Read ↗

Human INHBB Gene Variant (c.1079T>C:p.Met360Thr) Alters Testis Germ Cell Content, but Does Not Impact Fertility in Mice.Semantic proximity Read ↗

Inhibin Is an Antagonist of Bone Morphogenetic Protein SignalingSemantic proximity Read ↗

Betaglycan (TGFBR3) Functions as an Inhibin A, but Not Inhibin B, Coreceptor in Pituitary Gonadotrope Cells in MiceSemantic proximity Read ↗

Inhibin-A Antagonizes TGFβ2 Signaling by Down-Regulating Cell Surface Expression of the TGFβ Coreceptor BetaglycanSemantic proximity Read ↗

GDF9 modulates the reproductive and tumor phenotype of female inha-null mice.Semantic proximity Read ↗

Mutations in inhibin and activin genes associated with human disease.Semantic proximity Read ↗

Genetic Removal of Smad3 from Inhibin-Null Mice Attenuates Tumor Progression by Uncoupling Extracellular Mitogenic Signals from the Cell Cycle MachinerySemantic proximity Read ↗

Loss of Inhibin Advances Follicle Activation and Female Puberty Onset but Blocks Oocyte Maturation in ZebrafishSemantic proximity Read ↗

Homozygosity for a novel INHA mutation in two male siblings with hypospadias, primary hypogonadism, and high-normal testicular volume.Semantic proximity Read ↗

Activins Are Critical Modulators of Growth and SurvivalSemantic proximity Read ↗

WNT4/β-Catenin Pathway Maintains Female Germ Cell Survival by Inhibiting Activin βB in the Mouse Fetal OvarySemantic proximity Read ↗

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