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Article

Inhibin-A Antagonizes TGFβ2 Signaling by Down-Regulating Cell Surface Expression of the TGFβ Coreceptor Betaglycan

17 Feb 2010

Abstract excerpt

Inhibin is an atypical member of the TGFbeta family of signaling ligands and is classically understood to function via competitive antagonism of activin ligand binding. Inhibin-null (Inha-/-) mice develop both gonadal and adrenocortical tumors, the latter of which depend upon gonadectomy for initiation. We have previously shown that gonadectomy initiates adrenal tumorigenesis in Inha-/- mice by elevating...

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PMID: 20160125
DOI: 10.1210/me.2008-0374

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Related research

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Research trail→

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Inhibin-A Antagonizes TGFβ2 Signaling by Down-Regulating Cell Surface Expression of the TGFβ Coreceptor BetaglycanPMID 20160125Read ↗

Betaglycan (TGFBR3) Functions as an Inhibin A, but Not Inhibin B, Coreceptor in Pituitary Gonadotrope Cells in MiceSemantic proximity Read ↗

Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice.Semantic proximity Read ↗

Genetic Removal of Smad3 from Inhibin-Null Mice Attenuates Tumor Progression by Uncoupling Extracellular Mitogenic Signals from the Cell Cycle MachinerySemantic proximity Read ↗

Inhibin Is an Antagonist of Bone Morphogenetic Protein SignalingSemantic proximity Read ↗

Luteinizing hormone promotes gonadal tumorigenesis in inhibin-deficient mice.Semantic proximity Read ↗

Normal reproductive function in InhBP/p120-deficient mice.Semantic proximity Read ↗

GDF9 modulates the reproductive and tumor phenotype of female inha-null mice.Semantic proximity Read ↗

Origin and Identity of Adrenocortical Tumors in Inhibin Knockout Mice: Implications for Cellular Plasticity in the Adrenal CortexSemantic proximity Read ↗

Identification of distinct inhibin and transforming growth factor beta-binding sites on betaglycan: functional separation of betaglycan co-receptor actions.Semantic proximity Read ↗

Endogenous Betaglycan Is Essential for High-Potency Inhibin Antagonism in GonadotropesSemantic proximity Read ↗

Inhibin α-subunit N terminus interacts with activin type IB receptor to disrupt activin signaling.Semantic proximity Read ↗

Luteinizing Hormone and GATA4 Action in the Adrenocortical Tumorigenesis of Gonadectomized Female Mice.Semantic proximity Read ↗

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