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Article

Degradation of mutant initiator protein DnaA204 by proteases ClpP, ClpQ and Lon is prevented when DNA is SeqA-free.

The Biochemical journal - 15 Mar 2003

Slominska Monika, Wahl Anne, Wegrzyn Grzegorz, Skarstad Kirsten

Abstract excerpt

A mutant form of the Escherichia coli replication initiator protein, DnaA204, is unstable. At low growth rates, the dnaA204 mutant cells experience a limitation of initiator protein and grow with reduced initiation frequency and DNA concentration. The mutant DnaA protein is stabilized by the lack of SeqA protein. This stabilization was also observed in a dam mutant where the chromosome remains unmethylated. Since...

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PMID: 12479794
DOI: 10.1042/BJ20021161
PMCID: PMC1223233

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