Article
Widespread susceptibility among inbred mouse strains to the induction of lupus autoantibodies by pristane.
Clinical and experimental immunology - 1 Aug 2000
Satoh M, Richards H B, Shaheen V M, Yoshida H, Shaw M, Naim J O, Wooley P H, Reeves W H
Abstract excerpt
Unlike other agents associated with drug-induced lupus, the isoprenoid alkane pristane induces autoantibodies pathognomonic of lupus, including anti-Sm, anti-dsDNA, and anti-ribosomal P in BALB/c and SJL/J mice. The susceptibility of other strains of mice to pristane-induced lupus is unknown and is the focus of the present study. Anti-nRNP/Sm, anti-Su, and anti-ribosomal P autoantibodies were produced by most...
Topics
- Animals
- Antibodies, Antinuclear
- Autoantibodies
- Autoantigens
- Autoimmune Diseases
- Female
- Genetic Predisposition to Disease
- H-2 Antigens
- Haplotypes
- Housing, Animal
- Humans
- Immunoglobulin G
- K562 Cells
- Lupus Erythematosus, Systemic