Article
Fas and Fas ligand mutations inhibit autoantibody production in pristane-induced lupus.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2000
Satoh M, Weintraub J P, Yoshida H, Shaheen V M, Richards H B, Shaw M, Reeves W H
Abstract excerpt
Mutations of Fas (lpr) or Fas ligand (gld) cause a limited lupus-like syndrome in B6 mice by interfering with the deletion of autoreactive B and/or T cells. A more generalized lupus syndrome reminiscent of that of MRL mice can be induced in nonautoimmune strains by pristane, which causes a nonspecific inflammatory response in the peritoneal cavity. We hypothesized that, as in MRL mice, the lpr and gld mutations...
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